COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 129
● Weatherby & Ferguson: Iron Studies in Blood Chemistry
Screen (p.159-172)
Anemia
Anemia is defined by reduced levels of hemoglobin, hematocrit,
or red blood cells, which compromise the body's ability to deliver
oxygen efficiently. It often arises in response to chronic
inflammation4whether from illness, infection, or obesity. In such
states, the body lowers available iron to limit pathogen growth,
but this protective mechanism can also contribute to anemia.
Clinically, it's worth questioning whether iron supplementation
might worsen underlying inflammation or infection. Addressing the
root cause, rather than defaulting to iron replacement, may be
more effective.
Because symptoms like fatigue, dizziness, and shortness of breath
are nonspecific, lab testing is essential for identifying the type and
cause of anemia. A full panel4rather than isolated
markers4provides the clearest picture, as all components are
interrelated.
Differentiating between microcytic, macrocytic, and normocytic
anemia is key to uncovering the root issue and guiding treatment.
● Microcytic anemia involves smaller-than-normal red blood
cells (low MCV 3 mean corpuscular volume) and is
commonly linked to iron deficiency, inflammation, or
disrupted iron metabolism.
● Macrocytic anemia features enlarged red blood cells (high
MCV), often due to B12 or folate deficiency, especially in
cases of malabsorption.
● Normocytic anemia presents with normal-sized cells but
reduced quantity, often associated with chronic disease,
kidney issues, or early nutrient depletion.
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