COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 158
2. Analyze thyroid laboratory values through both conventional
and functional lenses
3. Recognize patterns of thyroid dysfunction that may be
missed in standard medical evaluation
4. Identify non-thyroidal factors that influence thyroid function
test results
5. Implement comprehensive assessment strategies for patients
with suspected thyroid imbalances
The Thyroid Hormonal Cascade
The Hypothalamic-Pituitary-Thyroid Axis
The regulation of thyroid function involves a sophisticated
feedback system known as the hypothalamic-pituitary-thyroid
(HPT) axis. Understanding this system is crucial for proper
interpretation of thyroid function tests [1].
Thyrotropin-Releasing Hormone (TRH)
TRH represents the initial signal in the thyroid cascade. This
tripeptide is synthesized in the hypothalamus and travels via the
hypothalamic-hypophyseal portal system to the anterior pituitary.
Its primary function is to stimulate the release of thyroid-stimulating
hormone (TSH) [2]. It's worth noting that TRH also stimulates
prolactin release, which explains some clinical observations where
thyroid and reproductive functions appear interconnected.
Thyroid-Stimulating Hormone (TSH)
TSH, also known as thyrotropin, is a glycoprotein produced by the
anterior pituitary gland in response to TRH stimulation. This
hormone serves as the master regulator of thyroid gland function
through several critical mechanisms [3]:
● Increases release of stored thyroid hormones
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