COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 211
Connection with Methylation Genes: There's an important
relationship between histamine metabolism and methylation
genes:
● HNMT requires adequate SAMe (S-adenosylmethionine) as a
methyl donor to function properly
● MTHFR mutations can impair methylation, reducing available
SAMe
● Individuals with both MTHFR and histamine metabolism SNPs
may experience compounded effects [32]
Understanding your specific genetic variants in histamine
metabolism pathways can help explain why you might be
particularly sensitive or resilient to histamine-containing foods and
guide personalized dietary and supplement strategies [33].
Additional Important SNPs
Beyond the major SNPs already discussed (MTHFR, COMT, MAO-A,
and APOE), several other genetic variants have significant
implications for health and personalized nutrition. Here are some
of the most clinically relevant:
VDR (Vitamin D Receptor)
Function: The VDR gene provides instructions for making the
vitamin D receptor protein, which allows the body to respond to
vitamin D [34]. This receptor is crucial for maintaining proper
calcium levels in the body and for many other processes including
immune function and cell growth.
Key Variants:
VDR Taq1 (rs731236)
Affects vitamin D receptor function and has been associated with
bone mineral density and autoimmune conditions.
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