COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 212
VDR Fok1 (rs2228570)
Influences the activity of the vitamin D receptor and can affect
immune response and inflammation.
Impact: Individuals with VDR SNPs may have altered responses to
vitamin D supplementation and different requirements for optimal
vitamin D levels. VDR variants have been studied in relation to:
● Bone health and osteoporosis risk
● Autoimmune diseases
● Cancer susceptibility
● Immune function
FTO (Fat Mass and Obesity-Associated Gene)
Function: The FTO gene is associated with energy regulation and
fat storage [35]. It encodes a protein involved in energy
homeostasis and contributes to weight regulation.
Key Variant:
FTO rs9939609
The A allele of this SNP is associated with increased BMI, weight,
and risk of obesity. The variant appears to affect appetite
regulation and food intake.
Impact: People with risk alleles in FTO may:
● Have increased appetite and reduced satiety
● Experience greater difficulty with weight management
● Benefit more significantly from personalized diet and exercise
interventions
● Respond differently to specific dietary patterns
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