COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 214
The T allele creates an upregulation of the CBS enzyme, potentially
increasing the breakdown of homocysteine and affecting sulfur
metabolism.
Impact: CBS variants may influence:
● Sulfur metabolism and sensitivity to high-sulfur foods
● Glutathione production
● Detoxification capacity
● Response to certain supplements like SAMe and NAC
SOD (Superoxide Dismutase)
Function: SOD genes encode enzymes that neutralize superoxide,
a harmful free radical. These enzymes are crucial components of
the body's antioxidant defenses [39].
Key Variants:
SOD2 A16V (rs4880)
Affects the mitochondrial form of SOD and has been associated
with oxidative stress and aging.
SOD3 R213G (rs2536512)
Influences the extracellular form of SOD and may impact
cardiovascular health.
Impact: SOD variants may affect:
● Susceptibility to oxidative stress-related conditions
● Cellular aging processes
● Response to environmental toxins
● Antioxidant requirements
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