COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 216
Impact: GST variants influence:
● Detoxification capacity
● Response to environmental toxins and certain medications
● Antioxidant status
● Potentially increased need for glutathione support
Understanding these additional SNPs can provide further insights
into personalized health strategies, expanding beyond the
well-known variants in MTHFR, COMT, MAO-A, and APOE. As with
all genetic information, these variants should be considered within
the context of the whole person, including environmental factors,
lifestyle, and comprehensive health assessment.
Practical Lifestyle Interventions Based on Specific SNP Results
Understanding your genetic variations is just the beginning. The
real power comes from implementing personalized lifestyle
interventions that address your specific genetic predispositions.
Here are evidence-based interventions for some of the most
common SNPs:
MTHFR Interventions
For individuals with MTHFR mutations (especially C677T and
A1298C), the following interventions may be beneficial [42][43]:
Dietary Modifications:
● Increase consumption of leafy greens, beets, and other
foods rich in natural folate
● Limit or avoid foods fortified with synthetic folic acid, which
may not be properly metabolized
● Ensure adequate protein intake to support methylation
pathways
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