COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 217
Supplement Considerations:
● Methylfolate instead of folic acid
● Methylcobalamin (B12) to support the methylation cycle
● B6 (as P5P, the active form) to support transsulfuration
pathways
● Magnesium and zinc as cofactors for methylation enzymes
● Consider reduced glutathione or its precursors (NAC) to
support detoxification
Lifestyle Factors:
● Minimize exposure to environmental toxins that burden
detoxification pathways
● Manage stress through mindfulness practices, as stress
depletes methylation resources
● Regular, moderate exercise to support cardiovascular health
and detoxification
COMT and MAO-A Interventions
For those with COMT and/or MAO-A SNPs that result in slower
enzyme activity [44][45]:
Dietary Considerations:
● Moderate consumption of catechol-rich foods (coffee,
chocolate, green tea) based on individual tolerance
● Balance protein intake to provide adequate amino acids
without excessive dopamine/catecholamine production
● Anti-inflammatory diet to reduce oxidative stress
Supplement Strategies:
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