COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 218
● Magnesium to support COMT function
● B vitamins (especially riboflavin/B2) to support methylation
and neurotransmitter metabolism
● SAMe (S-adenosylmethionine) to provide methyl groups for
COMT activity
● Adaptogens like rhodiola or ashwagandha to balance stress
response
Lifestyle Approaches:
● Stress management is crucial, as stress increases
catecholamine production
● Regular sleep schedule to support hormone balance and
neurotransmitter regulation
● Mind-body practices like meditation or yoga to regulate the
sympathetic nervous system
● Exercise at appropriate intensity (excessive high-intensity
exercise may exacerbate issues in some individuals)
APOE Interventions
For individuals with APOE variants, particularly those with one or
two ε4 alleles [46][47]:
Dietary Recommendations:
● Mediterranean diet patterns have shown benefit for APOE ε4
carriers
● Emphasize omega-3 fatty acids from marine sources
● Moderate saturated fat intake
● Include polyphenol-rich foods (berries, olive oil, green tea)
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