COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 220
● 42-year-old female
● History of treatment-resistant depression and anxiety
● Poor response to multiple SSRIs
● Chronic fatigue and brain fog
● Family history of cardiovascular disease
Genetic Testing Results:
● MTHFR C677T (+/+) homozygous
● COMT V158M (+/-) heterozygous
● MTRR A66G (+/+) homozygous
Intervention Approach: The practitioner developed a
comprehensive protocol focusing on supporting methylation
pathways. This included:
● Switching from folic acid supplements to methylfolate
(800mcg daily)
● Adding methylcobalamin (B12) 1000mcg sublingually
● Supplementing with P5P (active B6), magnesium glycinate,
and zinc
● Implementing an anti-inflammatory diet rich in leafy greens
and eliminating processed foods
● Addressing gut health through probiotics and digestive
support
● Incorporating daily mindfulness meditation and moderate
exercise
Outcome: Within 6 weeks, the patient reported significant
improvement in energy levels and mood stability. After 3 months,
depression symptoms had decreased by approximately 70%
based on standardized assessments. The patient's primary care
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