COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 223
● DHA/EPA supplementation (1000mg combined daily)
● Curcumin with enhanced bioavailability (500mg twice daily)
● Vitamin D optimization (tested and supplemented to achieve
blood levels of 50-70 ng/mL)
● Structured exercise program combining aerobic and
resistance training
● Cognitive training through language learning and musical
instrument practice
● Sleep optimization through behavioral and environmental
modifications
Outcome: After 6 months, the patient showed improvements in
cognitive testing scores, particularly in areas of executive function
and processing speed. Cardiovascular markers improved, with
reduction in blood pressure and improved lipid profiles. The
patient reported subjective improvements in memory and mental
clarity. While genetic risk cannot be eliminated, the
comprehensive approach appeared to slow progression and
improved quality of life [50].
Nutrigenomic Interactions: The Food-Gene Connection
Nutrigenomics examines how foods and their components
influence gene expression, metabolic pathways, and ultimately
health outcomes. This emerging field represents a crucial bridge
between genetic testing and practical dietary interventions,
offering insights into how dietary choices can modify genetic
predispositions [51].
The Science Behind Nutrigenomics
The fundamental principle of nutrigenomics is that food
components act as signals that can be detected by cellular
sensor systems, influencing gene expression, protein synthesis, and
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