COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 364
The Alzheimer's LINX™ panel evaluates immune reactivity across
seven distinct but interconnected categories, each representing a
critical dimension of potential Alzheimer's pathogenesis [9, 10]:
Brain Proteins
Amyloid Precursor Protein (APP)
The parent molecule from which amyloid-beta is derived
Tau Protein
Critical for structural support of neurons
Alpha-Synuclein
Associated with synaptic function and neurotransmitter release
Presenilin
Involved in processing of amyloid precursor protein
Apolipoprotein E (ApoE)
Important for lipid transport and structural integrity
Immune reactivity to these proteins may indicate early
autoimmune activity directed against crucial brain structures long
before clinical symptoms emerge [11, 12].
Growth Factors
Brain-Derived Neurotrophic Factor (BDNF)
Essential for neuronal growth and survival
Nerve Growth Factor (NGF)
Supports the survival of cholinergic neurons
Vascular Endothelial Growth Factor (VEGF)
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