COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 381
Systemic Inflammation Driver
Creates chronic low-grade inflammation that contributes to joint
pain, skin conditions, fatigue, and metabolic dysfunction
Nutrient Absorption Impact
Damages the absorptive capacity of the intestinal lining,
potentially leading to nutrient deficiencies despite adequate
dietary intake
Hormone Regulation Disruption
Affects production and metabolism of neurotransmitters and
hormones synthesized in the gut, influencing mood and endocrine
balance
The Blood-Brain Barrier: Guardian of Neurological Function
The blood-brain barrier (BBB) represents one of the most selective
and important protective interfaces in the body, strictly regulating
what enters the central nervous system [13, 14].
Specialized Endothelial Structure
Unique brain capillary cells with continuous tight junctions that are
50-100 times tighter than other tissues
Supportive Glial Components
Astrocytes with specialized end-feet that wrap around blood
vessels and enhance barrier function
Selective Transport Systems
Sophisticated carrier proteins that allow nutrients to enter while
blocking potentially harmful substances
Immune Cell Regulation
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