COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 382
Controlled mechanisms that prevent inappropriate immune cell
entry into brain tissue under normal conditions
Dynamic Barrier Function
Continuously responsive system that can be compromised by
systemic inflammation, stress, toxins, and infections
Cyrex Array 20: Blood-Brain Barrier Permeability Screen™
The Array 20 test provides the first accessible clinical assessment of
blood-brain barrier integrity through measurement of immune
reactivity to critical BBB proteins [15, 16].
S100B Protein Antibodies
Measures immune reactivity to a calcium-binding protein primarily
found in astrocytes, indicating damage to these key
barrier-supporting cells
Claudin-5 Antibodies
Detects responses against the primary tight junction protein
specific to brain endothelial cells, essential for BBB integrity
Occludin Antibodies
Identifies immune activity against another crucial tight junction
protein found in both intestinal and blood-brain barriers
Aquaporin-4 Antibodies
Evaluates reactivity to water channels concentrated in astrocyte
end-feet that regulate fluid balance at the blood-brain interface
Neurofilament Antibodies
Assesses immune responses to structural components of neurons,
indicating potential progression from barrier damage to neuronal
injury
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