COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 383
Clinical Significance of Blood-Brain Barrier Dysfunction
Compromise of the blood-brain barrier has profound implications
for neurological health and is increasingly recognized as a critical
factor in many brain disorders [19, 20].
Neurodegenerative Disease Connection
Barrier disruption appears early in conditions like Alzheimer's and
Parkinson's disease, often preceding significant symptom
manifestation
Neuroinflammatory Amplification
Allows pro-inflammatory molecules to enter brain tissue, triggering
microglial activation and creating chronic neuroinflammation
Cognitive Function Impact
Contributes to brain fog, memory difficulties, concentration
problems, and executive function challenges even before
diagnosable disease
Mood Regulation Disruption
Influences neurotransmitter balance and neuronal health,
potentially contributing to depression, anxiety, and mood
instability
Autoimmune Neurological Risk
Increases vulnerability to autoimmune attacks on brain tissue in
conditions like multiple sclerosis and autoimmune encephalitis
The Gut-Brain Barrier Axis: Bidirectional Communication
Research now confirms that intestinal barrier function directly
impacts blood-brain barrier integrity through multiple pathways,
creating an integrated system [21, 22].
Systemic Inflammation Pathway
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