COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 384
Inflammatory cytokines released due to intestinal permeability can
directly compromise blood-brain barrier tight junctions
Bacterial Translocation Effects
Microbiome-derived LPS and other toxins that cross a damaged
gut barrier can trigger neuroinflammation and BBB disruption
Vagus Nerve Signaling
Direct neural communication between gut and brain influenced
by intestinal barrier status and enteric nervous system function
Microbiome Metabolite Influence
Beneficial bacterial compounds that support both barriers are
reduced when intestinal dysbiosis or permeability occurs
Integrated Immune Response
Immune activation in the gut can trigger parallel responses
affecting the brain through circulating immune cells and signaling
molecules
Reversibility and Therapeutic Approaches
Early detection of barrier dysfunction enables targeted
interventions that can restore integrity and prevent disease
progression [8, 21].
Intestinal Barrier Restoration
Removal of inflammatory triggers, infection treatment,
microbiome rebalancing, and nutritional support for tight junction
repair
Anti-Inflammatory Nutrition
Personalized dietary interventions eliminating reactive foods while
incorporating barrier-supporting nutrients and phytocompounds
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