COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 388
Integrated Systems Perspective
Recognition of the gut-brain barrier axis as a critical factor in both
gastrointestinal and neurological health
Personalized Protocol Development
Evidence-based approach to creating individual treatment plans
based on specific barrier dysfunction patterns
Optimized Health Protection
Framework for long-term maintenance of barrier integrity as a
cornerstone of both neurological and immune resilience
This comprehensive approach to barrier assessment and
restoration represents one of the most promising frontiers in
functional medicine4addressing root causes of both neurological
and immune dysfunction before disease processes become
entrenched.
References
[1] Fasano A. Zonulin and its regulation of intestinal barrier
function: the biological door to inflammation, autoimmunity, and
cancer. Physiol Rev. 2011;91(1):151-175.
[2] Fasano A, Shea-Donohue T. Mechanisms of disease: the role of
intestinal barrier function in the pathogenesis of gastrointestinal
autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol.
2005;2(9):416-422.
[3] Rapin JR, Wiernsperger N. Possible links between intestinal
permeability and neurodegeneration. Neuro Endocrinol Lett.
2010;31(5):635-639.
[4] Fasano A. Intestinal permeability and its regulation by zonulin:
diagnostic and therapeutic implications. Clin Gastroenterol
Hepatol. 2012;10(10):1096-1100.
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