COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 396
● Gluteomorphin antibodies: Frequently linked to neurological
and cognitive symptoms, including brain fog, attention issues,
and mood disorders [18]
● TG6 antibodies: Strongly associated with neurological
symptoms, including ataxia, neuropathy, and headaches
[19]
● Multiple wheat peptide antibodies: Often seen in patients
with autoimmune comorbidities and more severe
symptomatology [20]
Cyrex Array 4: Gluten-Associated Cross-Reactive Foods and Food
Sensitivity
Understanding Cross-Reactivity in Gluten Sensitivity
Even when patients eliminate gluten, many continue to
experience symptoms. One significant reason for this is
cross-reactivity, where the immune system targets proteins in
non-gluten foods due to structural similarities with gluten proteins
[21]. This phenomenon, known as molecular mimicry, can
perpetuate inflammation and symptoms even on a strict
gluten-free diet [22].
What Array 4 Evaluates
Array 4 measures antibodies (IgA and IgG) against foods
commonly cross-reactive with gluten as well as foods frequently
introduced as substitutes in gluten-free diets:
Cross-Reactive Foods
These foods contain proteins structurally similar to gluten that may
trigger similar immune responses:
Dairy Proteins (Casein, Whey, Butyrophilin)
Dairy proteins, particularly alpha-casein, share structural homology
with gliadin peptides [23]
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