COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 436
Antibodies against gangliosides are frequently associated with
peripheral neuropathies, including Guillain-Barré syndrome
variants and chronic inflammatory demyelinating polyneuropathy
[25].
Synapsin
Synapsin is a neuronal phosphoprotein that regulates
neurotransmitter release at synapses [26]. It plays important roles
in:
● Synaptic plasticity and learning [27]
● Neurotransmitter regulation [28]
● Maintenance of synaptic vesicle pools [29]
● Formation and maintenance of synaptic contacts [30]
Antibodies against synapsin can disrupt normal neurotransmission
and contribute to various neuropsychiatric and
neurodevelopmental disorders [31].
Tubulin
Tubulin is a structural protein that forms microtubules, which are
essential components of the neuronal cytoskeleton [32]. Tubulin is
critical for:
● Axonal transport of cellular components [33]
● Maintenance of neuronal structure [34]
● Cell division and differentiation [35]
● Synaptic function [36]
Anti-tubulin antibodies can compromise neuronal structural
integrity and function, potentially contributing to
neurodegenerative processes [37].
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