COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 444
Elevated IgA antibodies against neural targets might suggest
addressing gut or mucosal barrier function as part of the
treatment strategy [123].
IgG Antibodies
IgG antibodies typically indicate a more established, chronic
immune response [124]:
● Their presence suggests a long-standing immune reaction
[125]
● They reflect immune memory against the targeted structures
[126]
● They often correlate with more chronic, established
symptoms [127]
● They may persist long after the initial triggering event [128]
IgG antibodies against neural targets indicate a need for more
comprehensive intervention to address established immune
reactivity [129].
The pattern of antibody classes present can provide valuable
insights into the nature, timing, and potential triggers of
neurological autoimmunity, guiding more precise and effective
intervention strategies [130].
The Reversibility of Neuroimmune Dysfunction
A critical question for patients and clinicians is whether
neuroimmune dysfunction can be reversed once detected. The
evidence suggests that early intervention offers the best
opportunity for meaningful improvement:
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