COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 445
Early Stage Reversibility
In the early stages, before significant tissue damage has occurred,
neuroimmune reactivity may be significantly reduced or reversed
with comprehensive intervention [131]:
● Clinical studies show that early intervention in multiple
sclerosis can significantly alter disease trajectory [132]
● Case reports document improvement in neuropsychiatric
symptoms with targeted immune-modulating therapies [133]
● Research in pediatric autoimmune neuropsychiatric disorders
demonstrates good response to early intervention [134]
● Animal models of neuroinflammation show greater
reversibility with early treatment [135]
The window of opportunity appears greatest when intervention
begins before chronic damage and neurodegeneration are
established [136].
Comprehensive Intervention Strategies
Effective reversal of neuroimmune dysfunction typically requires a
multi-faceted approach [137]:
Addressing Intestinal Permeability
Gut barrier dysfunction often precedes or accompanies
neuroinflammation [138]:
● Repairing gut permeability (which can be assessed with
Cyrex Array 2) is often a foundational step [139]
● Identifying and removing food triggers can reduce ongoing
immune stimulation [140]
● Supporting healthy gut microbiome composition helps
restore normal immune regulation [141]
● Addressing gut inflammation can reduce systemic
inflammation [142]
445
