COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 568
May indicate compromised mucosal immunity and barrier
function [33].
Neurological and Systemic Conditions
Brain Fog and Cognitive Issues
Often connected to mucosal-derived inflammatory mediators
affecting brain function [34].
Chronic Fatigue Syndrome
Frequently involves mucosal immune activation affecting systemic
energy regulation [35].
Fibromyalgia
Mucosal immune dysfunction and subsequent systemic
inflammation have been implicated in fibromyalgia
pathophysiology [36].
The Mucosal Immune System and Disease Development
Understanding how mucosal immune dysfunction contributes to
disease development is essential for effective clinical application
of Array 14 results:
The Mucosal-Systemic Connection
The traditional view of separate mucosal and systemic immune
compartments has given way to understanding their intimate
connection [37]. Research has demonstrated that immune
activation at mucosal surfaces can have profound systemic
effects through several mechanisms:
Cytokine Signaling
Inflammatory cytokines produced at mucosal surfaces enter the
circulation and affect distant organs and tissues [38].
Lymphocyte Trafficking
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