COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 570
Stage 1: Localized Mucosal Inflammation
Initial reactions remain confined to the mucosal surface, with
elevated specific sIgA antibodies but minimal systemic effects
[46].
Stage 2: Barrier Dysfunction
Continued inflammation damages tight junctions between
epithelial cells, increasing permeability and allowing greater
antigen exposure to the systemic immune system [47].
Stage 3: Systemic Immune Activation
As antigens penetrate compromised barriers, the systemic immune
system becomes activated, potentially leading to widespread
inflammation and autoimmunity [48].
Array 14 is particularly valuable for identifying Stage 1 and early
Stage 2 dysfunction before progression to systemic disease.
Can Mucosal Immune Dysfunction Be Reversed?
The potential for restoring healthy mucosal immune function
depends on several factors:
Stage of Dysfunction
Early-Stage Dysfunction
When identified in its early stages (localized mucosal inflammation
or early barrier compromise), mucosal immune dysfunction is
highly responsive to targeted interventions [49].
Advanced Dysfunction
Even in more advanced cases with systemic involvement,
significant improvement in mucosal immune function is possible,
though complete normalization may take longer [50].
Comprehensive Intervention Strategies
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