COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 592
Occludin
Forms the core structure of tight junctions and regulates their
stability [23, 24]
Junctional Adhesion Molecules (JAMs)
Contribute to intercellular adhesion and regulate leukocyte
trafficking [25, 26]
Zonula Occludens (ZO) Proteins
Scaffold proteins that link transmembrane tight junction proteins to
the actin cytoskeleton [27, 28]
What Array 20 Checks For
Array 20 evaluates antibody responses against specific
blood-brain barrier proteins, providing a window into BBB integrity
through detection of immune reactions to key structural elements
[29, 30]:
S100B
A calcium-binding protein primarily produced by astrocytes,
serving as a marker of astrocyte integrity and brain barrier health
[31, 32]
Claudin-5 and Occludin
Proteins critical for tight junctions in the blood-brain barrier,
maintaining the structural integrity of the barrier [33, 34]
Aquaporin-4
Water channel protein involved in brain fluid balance and
blood-brain interface maintenance, predominantly expressed in
astrocyte endfeet [35, 36]
Matrix Metalloproteinases (MMPs)
592
