COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 593
Enzymes involved in extracellular matrix remodeling that can
compromise BBB integrity when overactivated [37, 38]
Transthyretin (TTR)
A transport protein that carries thyroxine and retinol across the
blood-CSF barrier, with monomeric forms potentially indicating
barrier disruption [39, 40]
Platelet-Derived Growth Factor Receptor-β (PDGFR-β)
A receptor expressed on pericytes that is crucial for BBB
development and maintenance [41, 42]
Detection of immune responses against these proteins reveals
whether the BBB is compromised and vulnerable to inflammatory
or autoimmune attacks, providing valuable insight into
neurological health [43, 44].
The Significance of Antibody Class Assessment
Array 20 measures three different antibody classes against each
target, providing a comprehensive timeline of immune
dysregulation:
IgM Reactivity
Often indicates a more recent or acute breach of the blood-brain
barrier [45, 46]
IgA Reactivity
May reflect mucosal-driven immune activation crossing into the
brain, suggesting a gut-brain connection in BBB disruption [47, 48]
IgG Reactivity
Suggests chronic, ongoing blood-brain barrier compromise with
established immune memory responses [49, 50]
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