COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 595
Detecting barrier dysfunction early offers a critical window to
intervene before significant brain damage occurs, positioning
Array 20 as an important clinical tool for preventive neurology [65,
66].
Conditions Where Array 20 is Especially Valuable
Array 20 testing provides particular clinical value in the following
conditions:
Mild Traumatic Brain Injury
Concussion and post-concussion syndrome frequently involve BBB
disruption that may persist beyond symptomatic recovery [67, 68]
Neurodegenerative Disorders
Alzheimer's disease, Parkinson's disease, and multiple sclerosis
feature BBB dysfunction as both a contributor to and
consequence of pathology [69, 70]
Autoimmune Neurological Diseases
Autoimmune encephalitis, neuropsychiatric lupus, and other
neuroimmune conditions involve antibody-mediated BBB damage
[71, 72]
Chronic Fatigue Syndrome and Fibromyalgia
Evidence suggests BBB permeability changes may contribute to
neuroinflammation and central sensitization in these conditions
[73, 74]
Chronic Inflammatory Response Syndrome (CIRS)
Biotoxin exposure can trigger BBB compromise and
neuroinflammation as part of a multi-system inflammatory
response [75, 76]
Chronic Gut Inflammation and Leaky Gut Syndromes
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