COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 598
Measures cerebral blood flow which can be altered in BBB
dysfunction [103, 104]
Magnetic Resonance Spectroscopy (MRS)
Detects metabolic changes associated with neuroinflammation
and BBB disruption [105, 106]
Novel Biomarker Approaches
Extracellular Vesicles
Circulating exosomes containing BBB-derived proteins may serve
as liquid biopsy markers [107, 108]
MicroRNAs
Specific miRNA profiles are associated with BBB dysfunction in
various neurological conditions [109, 110]
Metabolomic Signatures
Patterns of metabolites in blood or CSF can reflect BBB
compromise and brain metabolic alterations [111, 112]
Peripheral Inflammatory Profiles
Specific cytokine patterns correlate with BBB permeability
changes and neuroinflammation [113, 114]
Integration of these multiple assessment approaches with Array 20
results provides the most comprehensive picture of BBB integrity
and its relationship to neurological health [115, 116].
Can Blood-Brain Barrier Damage Be Reversed?
In many early cases, evidence supports the potential for BBB repair
and restoration of function. Effective strategies include:
Identifying and Removing Inflammatory Triggers
598
