COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 599
Addressing gut dysbiosis, infections, environmental toxins, and
chemical exposures that contribute to systemic inflammation [117,
118]
Healing Gut Permeability
Treating intestinal hyperpermeability to reduce systemic endotoxin
load, often a key driver of BBB disruption [119, 120]
Anti-inflammatory Interventions
Specialized pro-resolving mediators (SPMs), omega-3 fatty acids,
resveratrol, curcumin, and other natural compounds that target
neuroinflammation [121, 122]
Antioxidant Support
N-acetyl cysteine, glutathione precursors, and other compounds
that neutralize oxidative stress and protect BBB integrity [123, 124]
Rebuilding Blood-Brain Barrier Tight Junctions
Targeted nutrients that support tight junction protein expression
and function, including specific amino acids and phospholipids
[125, 126]
Neurovascular Coupling Enhancement
Interventions that improve the coordination between neuronal
activity and cerebral blood flow [127, 128]
Circadian Rhythm Optimization
Proper sleep-wake cycles support glymphatic clearance and BBB
maintenance [129, 130]
Protecting and repairing the blood-brain barrier can slow or even
partially reverse cognitive and neurological deterioration if
addressed promptly, particularly when guided by specific
biomarker patterns identified through Array 20 testing [131, 132].
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