COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 603
A 72-year-old with progressive cognitive decline showed
predominantly IgG antibodies to BBB proteins on Array 20,
indicating chronic barrier dysfunction. Additional testing revealed
elevated neuronal autoantibodies on Array 7X and significant
dysbiosis.
While the long-standing nature of the condition presented greater
challenges, a comprehensive protocol addressing gut health,
neuroinflammation, and BBB integrity achieved stabilization of
cognitive function and improvement in quality of life measures.
Serial cognitive assessments over 18 months showed no further
decline, and follow-up Array 20 testing demonstrated partial
reduction in antibody levels, suggesting some restoration of BBB
function ePattern Analysis
Different patterns of antibody reactivity on Array 20 provide
important clinical insights for treatment planning:
Predominant IgM Elevation
Suggests recent BBB disruption requiring rapid intervention focused
on removing triggers and providing acute barrier support [161,
162]
Predominant IgA Elevation
Indicates mucosal-driven mechanisms requiring primary focus on
gut barrier restoration and microbiome modulation [163, 164]
Predominant IgG Elevation
Reflects chronic BBB compromise necessitating longer-term,
comprehensive approaches to restore barrier function [165, 166]
Mixed Antibody Patterns
Suggests ongoing active processes superimposed on chronic
dysfunction, requiring multilayered intervention strategies [167,
168]
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