COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 607
Integration Potential
Complements other functional assessments to create a complete
picture of brain health and systemic influences [207, 208]
As research continues to elucidate the central role of BBB integrity
in neurological health and disease, Array 20 testing is positioned to
become an increasingly valuable component of comprehensive
neurological assessment and treatment [209, 210].
References
[1] Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb
Perspect Biol. 2015;7(1):a020412.
[2] Sweeney MD, Zhao Z, Montagne A, et al. Blood-brain barrier:
from physiology to disease and back. Physiol Rev. 2019;99(1):21-78.
[3] Profaci CP, Munji RN, Pulido RS, Daneman R. The blood-brain
barrier in health and disease: important unanswered questions. J
Exp Med. 2020;217(4):e20190062.
[4] Nation DA, Sweeney MD, Montagne A, et al. Blood-brain
barrier breakdown is an early biomarker of human cognitive
dysfunction. Nat Med. 2019;25(2):270-276.
[5] Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier
breakdown in Alzheimer disease and other neurodegenerative
disorders. Nat Rev Neurol. 2018;14(3):133-150.
[6] Chow BW, Gu C. The Molecular Constituents of the Blood-Brain
Barrier. Trends Neurosci. 2015;38(10):598-608.
[7] Greene C, Campbell M. Tight junction modulation of the blood
brain barrier: CNS delivery of small molecules. Tissue Barriers.
2016;4(1):e1138017.
[8] Vojdani A. Immunological mechanisms of brain barrier
breakdown. Clin Rev Allergy Immunol. 2015;49(2):148-158.
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