COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 630
The small intestine normally contains relatively few bacteria
compared to the colon. When this delicate balance is disrupted,
bacteria from the large intestine can migrate upward and
colonize the small intestine, creating a condition known as SIBO
[2]. These misplaced bacteria produce toxins, ferment
carbohydrates inappropriately, and trigger immune responses
against both bacterial components and the intestinal barrier itself.
What is Cyrex Array 22?
The Array 22 Irritable Bowel/SIBO Screen™ from Cyrex Laboratories
measures immune system activity against bacterial toxins and
structural components of the gut lining [3]. It evaluates IgG, IgA,
and IgM antibodies to determine whether bacterial overgrowth
and toxin exposure have triggered early immune dysfunction in
the small intestine.
This test provides critical insight into the relationship between SIBO
and its consequences: gut permeability, chronic inflammation,
and systemic immune activation. Unlike standard SIBO breath
testing that only detects bacterial gas production, Array 22
identifies whether bacterial presence has triggered potentially
harmful immune responses [4].
Comprehensive Markers Evaluated by Array 22
Array 22 screens for immune reactivity to:
Bacterial Toxins and Components
● Lipopolysaccharides (LPS): Cell wall components of
gram-negative bacteria that potently activate immune
responses
● Flagellin: A protein that forms bacterial flagella and can
trigger strong immune reactions
● Bacterial Cytotoxins: Toxins produced by certain bacterial
species that damage intestinal cells
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