COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 631
● Bacterial Translocation Products: Components that indicate
bacteria have moved across intestinal barriers
Intestinal Barrier Proteins
● Occludin: A critical tight junction protein that maintains
intestinal barrier integrity
● Zonulin: A protein that regulates intestinal permeability by
modifying tight junctions
● Actomyosin: Structural proteins in intestinal cells that support
barrier function
By measuring immune responses to these targets, Array 22 detects
whether bacteria-driven gut dysfunction has begun to
compromise immune tolerance and gut barrier health [5].
The Clinical Significance of Antibody Classes
Array 22 measures three different antibody classes against each
target, providing a comprehensive timeline of immune
dysregulation:
● IgM positivity: Typically reflects a recent or active immune
reaction against bacterial toxins or gut tissue. These
antibodies are the first to appear in an immune response and
suggest ongoing bacterial challenges to the gut [6].
● IgA positivity: Suggests mucosal immune dysregulation, often
involving intestinal barrier damage. As the primary antibody
at mucosal surfaces, elevated IgA indicates the intestinal
immune system is actively responding to bacterial
overgrowth or barrier disruption [7].
● IgG positivity: Indicates a chronic, memory-based immune
response, reflecting longer-standing intestinal dysfunction.
These antibodies develop later and persist longer, pointing to
established gut dysfunction requiring more comprehensive
intervention [8].
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