COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 647
Acids Testing (OAT), comprehensive stool analysis like BiomeFX,
and immune assessment via Cyrex Array 22 - offer complementary
perspectives on gut function. Understanding when to use each
test, either individually or in combination, enables more precise
clinical decision-making and targeted interventions [1].
Organic Acids Testing (OAT)
Overview and Mechanism
Organic acids testing analyzes metabolic intermediates excreted
in urine that reflect both human cellular metabolism and microbial
activity. By measuring these compounds, clinicians gain insight
into metabolic processes, mitochondrial function, neurotransmitter
metabolism, and intestinal microbial activity [2].
Primary Clinical Applications
OAT is particularly valuable in these clinical scenarios:
Suspected Metabolic Dysfunction
When symptoms suggest impaired energy production,
mitochondrial dysfunction, or metabolic issues, OAT can reveal
specific biochemical blocks. These may include fatigue, exercise
intolerance, or metabolic disturbances that accompany gut
dysfunction [3].
Suspected Fungal Overgrowth
OAT measures specific markers of yeast and fungal metabolism
such as D-arabinitol, which can identify fungal overgrowth that
might be missed on standard stool testing [4].
Neurocognitive Symptoms
The test evaluates neurotransmitter metabolites and their
precursors, making it useful when gut issues present alongside
anxiety, depression, brain fog, or other cognitive symptoms [5].
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