COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 650
Suspected SIBO with Immune Activation
When small intestinal bacterial overgrowth is suspected,
particularly when it appears to involve immune system activation
leading to persistent symptoms despite treatment [15].
Chronic IBS Unresponsive to Standard Approaches
For patients with irritable bowel syndrome who have not
responded adequately to standard dietary and antimicrobial
interventions, suggesting immune involvement [16].
Suspected Intestinal Permeability
When symptoms or history suggest compromised intestinal barrier
function, Array 22's assessment of antibodies to barrier proteins like
occludin and zonulin provides valuable insight [17].
Systemic Symptoms with Suspected Gut Origin
In cases where extraintestinal manifestations (joint pain, skin issues,
fatigue) may stem from bacterial translocation or molecular
mimicry mechanisms [18].
Key Advantages
● Evaluates the immune system's response to bacterial
components
● Identifies intestinal barrier compromise
● Helps determine whether antimicrobial therapy alone is
sufficient or if immune modulation is also needed
● Provides insight into potential mechanisms for systemic
symptoms of gut origin [19]
Clinical Decision-Making: Which Test When?
Single Test Scenarios
650
