COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 653
In complex cases with multisystem involvement, persistent
symptoms despite intervention, or diagnostic uncertainty, all three
tests may be warranted to provide the most complete picture of
gut function, metabolism, and immune activation [26].
Sequential Testing Strategy
Often, a phased approach to testing is most practical and
cost-effective:
First-Line Testing
For most patients with digestive complaints without significant
systemic involvement, BiomeFX or similar comprehensive stool
analysis provides the most directly relevant initial information
about gut function and microbiome status [27].
Second-Line Testing
Based on initial findings and clinical response:
● If stool testing reveals dysbiosis but treatment yields
incomplete improvement, Cyrex Array 22 can evaluate
whether immune activation is maintaining symptoms [28].
● If symptoms suggest metabolic involvement beyond what's
revealed in stool testing, OAT can provide the next layer of
information [29].
Comprehensive Assessment
For patients with complex presentations, treatment resistance, or
significant systemic involvement, moving directly to a
comprehensive assessment using all three modalities may be more
efficient and cost-effective in the long run, preventing prolonged
suffering and unnecessary interventions [30].
Clinical Case Examples
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