COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 654
Case 1: Post-Infectious IBS
A 34-year-old female developed persistent bloating, abdominal
pain, and alternating bowel habits following food poisoning. Initial
testing with BiomeFX revealed moderate dysbiosis but treatment
with antimicrobials and probiotics yielded only partial
improvement. Subsequent Cyrex Array 22 testing showed
elevated antibodies to bacterial LPS and occludin, indicating
immune activation and barrier compromise driving ongoing
symptoms. Adding targeted barrier support and immune
modulation to her protocol resulted in significant clinical
improvement [31].
Case 2: SIBO with Systemic Symptoms
A 45-year-old male presented with confirmed SIBO (positive
breath test) alongside fatigue, muscle pain, and cognitive
difficulties. Initial antimicrobial treatment improved digestive
symptoms but not systemic complaints. Combined OAT and Cyrex
Array 22 testing revealed markers of mitochondrial dysfunction,
toxin-producing bacteria, and elevated antibodies to bacterial
cytotoxins. A protocol addressing both immune activation and
mitochondrial support led to resolution of systemic symptoms [32].
Case 3: Complex Multi-System Presentation
A 52-year-old female with longstanding digestive issues, fatigue,
joint pain, and recurring skin rashes had previously undergone
multiple rounds of treatment with minimal improvement.
Comprehensive testing with all three modalities revealed:
● OAT: Markers of mitochondrial dysfunction and fungal
overgrowth
● BiomeFX: Low diversity, opportunistic overgrowth, and
digestive insufficiency
● Cyrex Array 22: Multiple bacterial toxin antibodies and barrier
protein antibodies
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