COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 659
[34] Round JL, Mazmanian SK. The gut microbiota shapes intestinal
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Total Serum IgG/IgA/IgM Panel: A Comprehensive
Guide
Introduction
The Total Serum IgG/IgA/IgM Panel, commonly performed through
Cyrex Laboratories, is a fundamental immunological assessment
that measures the concentration of the three major classes of
immunoglobulins in serum [1]. This panel serves as a cornerstone
diagnostic tool for evaluating overall immune system function,
detecting immunodeficiencies, and monitoring immune-mediated
conditions [2,3].
Understanding Immunoglobulin Structure and Function
Immunoglobulin G (IgG)
● Comprises approximately 70-80% of all serum
immunoglobulins [4]
● Primary antibody in secondary immune responses
● Crosses the placental barrier, providing passive immunity to
newborns [5]
● Four subclasses (IgG1-IgG4) with distinct functional properties
[6]
● Half-life of approximately 21-24 days [7]
● Functions include:
○ Long-term memory against viral and bacterial
pathogens
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