COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 661
Normal Reference Ranges
Immunoglobulin
Adult
Reference
Range (g/L)
Pediatric Variations
IgG
7.0-16.0
Age-dependent increases [19]
IgA
0.7-4.0
Adult levels by age 15 [20]
IgM
0.4-2.3
Relatively stable after infancy [21]
Pattern Recognition
Immunodeficiency Patterns
Primary Immunodeficiencies
○ Common Variable Immunodeficiency (CVID): Low IgG
with decreased IgA and/or IgM [22]
○ Selective IgA Deficiency: IgA < 0.07 g/L with normal IgG
and IgM [23]
○ Specific Antibody Deficiency: Normal total Ig levels but
poor vaccine responses [24]
Secondary Immunodeficiencies
○ Malnutrition: Generalized decrease in all
immunoglobulins [25]
○ Protein-losing enteropathy: Primarily affects IgG due to
longer half-life [26]
○ Lymphoproliferative disorders: Variable patterns
depending on type [27]
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