COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 662
Hyperimmune States
Chronic Infections
○ Persistent bacterial infections: Elevated IgG and IgA [28]
○ Parasitic infections: Often associated with elevated IgM
[29]
Autoimmune Disorders
○ Rheumatoid arthritis: Elevated IgG and IgM [30]
○ Sjögren's syndrome: Polyclonal increase in
immunoglobulins [31]
○ Systemic lupus erythematosus: Variable patterns [32]
Chronic Inflammatory States
○ Inflammatory bowel disease: Elevated IgG and IgA [33]
○ Celiac disease: Elevated IgA (prior to treatment) [34]
Advanced Clinical Applications
Gut-Immune Axis Assessment
The Total Serum IgG/IgA/IgM Panel is particularly valuable in
evaluating gut-immune axis dysfunction:
● Low serum IgA correlates with compromised mucosal barrier
function [35]
● IgA deficiency increases risk of food allergies and
autoimmune diseases [36]
● Elevated IgG may reflect chronic intestinal inflammation or
food sensitivities [37]
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