COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 686
Autoimmune Diseases
Autoimmune conditions involve complex immune dysregulation
that can be better characterized through detailed lymphocyte
analysis [113, 114]:
Systemic Lupus Erythematosus (SLE)
Often features abnormal T-cell activation, regulatory T-cell
dysfunction, and B-cell hyperactivity [115, 116]
Rheumatoid Arthritis (RA)
Typically exhibits TH1/TH17 predominance, activated T-cells, and
regulatory T-cell imbalances [117, 118]
Multiple Sclerosis (MS)
Characterized by TH1/TH17 dominance, regulatory T-cell
dysfunction, and activated T-cells [119, 120]
Hashimoto's Thyroiditis
Often shows TH1 dominance with regulatory T-cell abnormalities
[121, 122]
Chronic Infections
Persistent infections frequently involve specific patterns of immune
dysregulation [123, 124]:
Epstein-Barr Virus (EBV)
May feature NK cell dysfunction, CD8+ T-cell exhaustion, and
regulatory imbalances [125, 126]
Cytomegalovirus (CMV)
Often associated with expanded CD8+ T-cell populations and
immune senescence patterns [127, 128]
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