COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 690
Excessive production of IFN-µ, TNF-³, and IL-2 driving inflammatory
cascades [173, 174]
Macrophage Activation
Enhanced activation of tissue-resident macrophages contributing
to local inflammation [175, 176]
Cytotoxic T-cell Stimulation
Increased CD8+ T-cell activity potentially targeting self-tissues [177,
178]
Cell-Mediated Autoimmunity
Development of autoimmune conditions like type 1 diabetes,
multiple sclerosis, and Crohn's disease [179, 180]
Excessive TH2 Response
A hyperactive TH2 pathway can promote allergic reactions and
certain forms of autoimmunity [181, 182]:
Allergic Sensitization
Enhanced production of IL-4, IL-5, and IL-13 promoting IgE
production and allergic responses [183, 184]
Eosinophil and Mast Cell Activation
Increased recruitment and activation of allergy-mediating cells
[185, 186]
Impaired Antiviral Defense
Reduced capacity to effectively combat viral infections [187, 188]
Antibody-Mediated Autoimmunity
Development of conditions like systemic lupus erythematosus and
pemphigus [189, 190]
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