COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 764
● Reduced inflammatory markers in metabolic syndrome [18]
● Favorable responses to caloric restriction [19]
● Better outcomes in cancer immunotherapy [20]
● Improved cardiovascular health markers [21]
Low levels may indicate barrier dysfunction and increased
susceptibility to metabolic conditions [22].
Faecalibacterium prausnitzii
As a major butyrate producer, this organism:
● Provides anti-inflammatory effects [23]
● Supports colonocyte health [24]
● Helps maintain gut barrier integrity [25]
● Modulates immune function [26]
● Produces specialized anti-inflammatory proteins [27]
● Regulates T-regulatory cell development [28]
● Enhances intestinal hypoxia-inducible factor signaling [29]
● Promotes appropriate mucin secretion [30]
F. prausnitzii depletion is observed in:
● Inflammatory bowel disease (particularly Crohn's disease)
[31]
● Colorectal cancer [32]
● Irritable bowel syndrome [33]
● Celiac disease [34]
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