COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 770
● Prevents accumulation of inhibitory fermentation products
[115]
M. smithii abundance correlates with:
● Constipation-predominant IBS presentations [116]
● Efficiency of caloric extraction from diet [117]
● Specific patterns of bloating and distension [118]
● Slower intestinal transit [119]
● Methanogenic breath test results [120]
Targeted reduction strategies may benefit specific clinical
presentations [121].
Emerging Keystone Species
Recent research has identified additional microorganisms with
potential keystone functions:
Roseburia species
These butyrate-producing organisms function as keystones by:
● Converting acetate to butyrate through cross-feeding [122]
● Producing specialized anti-inflammatory factors [123]
● Supporting mucin production and barrier integrity [124]
● Modulating local and systemic immune function [125]
● Influencing colonic pH and redox conditions [126]
● Competing with sulfate-reducing bacteria [127]
● Enhancing colonocyte metabolism and health [128]
● Contributing to bile acid transformation [129]
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