COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 771
Roseburia depletion is associated with various inflammatory
conditions and metabolic disturbances [130].
Eubacterium rectale
This organism has gained recognition as a pivotal keystone
through:
● Specialized starch utilization capabilities [131]
● Production of multiple SCFA types [132]
● Mucosal interaction that supports epithelial health [133]
● Anti-inflammatory protein production [134]
● Regulation of intestinal serotonin production [135]
● Influence on circadian rhythm entrainment [136]
● Cross-feeding relationships with other beneficial bacteria
[137]
● Production of specialized bacteriocins [138]
E. rectale appears particularly important in maintaining proper
neuroendocrine signaling between gut and systemic physiology
[139].
Alistipes species
These emerging keystones influence host health through:
● Production of unique secondary bile acids [140]
● Specialized sphingolipid metabolism [141]
● Interactions with tryptophan and serotonin pathways [142]
● Regulation of intestinal inflammation [143]
● Contribution to specialized SCFA profiles [144]
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