COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 773
Keystone species distribution varies significantly across human
populations in ways that reflect evolutionary adaptation:
Traditional vs. Western Populations
● Traditional hunter-gatherer populations (e.g., Hadza,
Yanomami) show higher abundance of fiber-degrading
keystones like Prevotella and unique Treponema species
[158]
● Industrialized populations exhibit higher Bacteroides and
lower overall diversity [159]
● Rural agrarian communities demonstrate intermediate
patterns with unique keystone signatures [160]
● Island populations often possess endemic keystone variants
adapted to local dietary patterns [161]
● Nomadic populations show seasonal cycling of different
keystone communities [162]
Dietary Pattern Influences
● Mediterranean diets favor Faecalibacterium, Roseburia, and
polyphenol-metabolizing keystones [163]
● High-protein diets may promote proteolytic keystones like
certain Bacteroides species [164]
● Plant-based diets enhance fiber-degrading keystones such
as Ruminococcus and Prevotella [165]
● Ketogenic diets select for unique keystones involved in fatty
acid metabolism [166]
● Traditional fermented food consumption correlates with
enhanced keystone stability [167]
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