COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 778
● Perturbation response modeling to assess keystone resilience
[214]
● Simulation of keystone removal effects on community
structure [215]
● Identification of keystone-dependent microbial guilds [216]
These advanced techniques allow for more precise intervention
planning based on specific keystone deficiencies and their
ecological context [217].
Postbiotic Derivatives of Keystone Species
Beyond live microorganisms, the metabolites and cellular
components of keystone species offer therapeutic potential:
Short-Chain Fatty Acids
● Butyrate, propionate, and acetate supplements mimicking
keystone outputs [218]
● Targeted delivery systems for colonocyte-specific SCFA
delivery [219]
● SCFA precursors that enhance endogenous production [220]
● SCFA receptor agonists activating host pathways [221]
● Combined SCFA approaches reflecting natural keystone
profiles [222]
Anti-Inflammatory Factors
● Purified MAM protein from F. prausnitzii with potent
anti-inflammatory effects [223]
● Akkermansia-derived membrane proteins that enhance
barrier function [224]
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