COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 780
These postbiotic approaches may offer advantages in specific
clinical contexts where live organism administration is challenging
or insufficient [238].
Ecological Restoration vs. Single Species Supplementation
The most effective approaches to keystone restoration consider
ecological context:
Limitations of Single-Species Interventions
● Many keystone species require specific ecological niches to
function properly [239]
● Isolated keystones often fail to engraft without supporting
community members [240]
● Single species may not address underlying ecological
disruptions [241]
● Colonization resistance may prevent establishment without
ecosystem preparation [242]
● Host factors may inhibit keystone function despite adequate
supplementation [243]
Ecosystem-Based Approaches
● Community preparation before keystone introduction [244]
● Staged introduction of complementary species [245]
● Removal of antagonistic factors inhibiting keystone
establishment [246]
● Creation of appropriate environmental conditions (pH, redox,
nutrients) [247]
● Management of host factors affecting microbial colonization
[248]
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