COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 781
● Long-term support for keystone stability and function [249]
● Ongoing monitoring of ecosystem development and
keystone integration [250]
The distinction between simply adding keystone species versus
restoring proper ecological context represents a paradigm shift in
microbiome-based therapeutics [251].
Future Directions: Keystone-Centric Therapeutics
The future of microbiome-based interventions lies in
comprehensive approaches that:
1. Identify patient-specific keystone deficiencies through
advanced testing [252]
2. Assess the broader ecological context affecting keystone
function [253]
3. Implement targeted interventions to restore keystone species
[254]
4. Support the establishment of proper ecological networks
[255]
5. Monitor functional outcomes rather than just microbial
abundance [256]
6. Adapt therapeutic approaches based on ecological
responses [257]
7. Address host factors that influence keystone colonization
[258]
8. Build resilience through ecosystem-wide approaches [259]
9. Integrate keystone restoration with appropriate dietary and
lifestyle modifications [260]
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