COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 782
10. Develop personalized approaches based on individual
ecological patterns [261]
11. Utilize synthetic biology to enhance keystone function
where appropriate [262]
12. Combine live biotherapeutics with postbiotic derivatives
for enhanced effectiveness [263]
By focusing on these ecological linchpins rather than simply
eliminating pathogens, practitioners can achieve more sustained
therapeutic outcomes with reduced relapse rates and improved
patient quality of life [264].
References
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[2] Fisher CK, Mehta P. Identifying keystone species in the human
gut microbiome from metagenomic timeseries using sparse linear
regression. PLoS One. 2014;9(7).
[3] Berry D, Widder S. Deciphering microbial interactions and
detecting keystone species with co-occurrence networks. Front
Microbiol. 2014;5:219.
[4] Vieira-Silva S, Falony G, Darzi Y, et al. Species-function
relationships shape ecological properties of the human gut
microbiome. Nat Microbiol. 2016;1(8):16088.
[5] Desai MS, Seekatz AM, Koropatkin NM, et al. A dietary
fiber-deprived gut microbiota degrades the colonic mucus barrier
and enhances pathogen susceptibility. Cell. 2016;167(5):1339-53.
[6] Coyte KZ, Schluter J, Foster KR. The ecology of the microbiome:
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