COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 838
Clostridia and Other Bacterial Markers
HPHPA is produced by several Clostridia species and correlates
with neurological symptoms. 4-cresol indicates overgrowth of
certain bacteria and can contribute to toxic burden. These
markers often correlate with neuropsychiatric symptoms.
Benzoate Metabolism
Benzoate metabolites reflect both dietary intake and microbial
metabolism. Abnormal hippurate suggests compromised phase II
detoxification.
Treatment Approaches for Microbial Imbalances
Antifungal protocols (herbal or pharmaceutical) for elevated
yeast markers Targeted antimicrobial support for specific bacterial
overgrowth Prebiotics and probiotics to restore microbial balance
Biofilm disruptors for persistent infections Dietary modifications to
address microbial imbalances
Detoxification Markers
Pyroglutamic Acid
Interpretation
Elevation indicates glutathione depletion and compromised
phase II detoxification.
2-Methylhippuric Acid, Orotic Acid
Interpretation
Elevations suggest impaired phase I detoxification or ammonia
processing issues.
Clinical Significance of Detoxification Markers
These markers reveal the body's capacity to handle toxins and
metabolic waste:
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