COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 839
Glutathione Status
Pyroglutamic acid elevations indicate glutathione depletion. This
compromises the body's master antioxidant and detoxification
system. Often correlates with oxidative stress, toxic exposure, and
chronic illness.
Phase I and II Detoxification
Methylhippuric acid reflects phase II conjugation of environmental
toxins. Abnormalities suggest impaired ability to clear toxins.
Ammonia Metabolism
Orotic acid elevations indicate impaired ammonia processing in
the urea cycle. This can affect neurological function and energy
production.
Treatment Approaches for Detoxification Issues
Glutathione support (NAC, alpha-lipoic acid, glycine, glutamine) B
vitamins to support methylation and detoxification pathways
Molybdenum for sulfite sensitivity Limiting toxic exposure
Supporting liver function with herbs like milk thistle and dandelion
Vitamin and Nutrient Markers
B-Vitamin Markers
Methylmalonic acid (B12), Formiminoglutamic acid (folate),
Xanthurenic acid (B6), Kynurenic acid (B6)
Interpretation
Elevations suggest specific B-vitamin deficiencies.
Vitamin C Markers
Ascorbic acid
Interpretation
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